Corosolic acid-modified lipid nanoparticles as delivery carriers for DNA vaccines against avian influenzaArticle Published on 2023-05-102023-06-02 Journal: International journal of pharmaceutics [Category] 조류인플루엔자, [키워드] Avian influenza vaccine cholesterol Corosolic acid immune responses Lipid nanoparticles. [DOI] 10.1016/j.ijpharm.2023.122914 PMC 바로가기
Role of cholesterol-recognition motifs in the infectivity of SARS-CoV-2 variantsArticle Published on 2023-02-012023-07-11 Journal: Colloids and surfaces. B, Biointerfaces [Category] COVID19(2023년), [키워드] Cell-surface phenomena cholesterol Cholesterol recognition motifs Cholesterol-protein interactions fusion proteins viral infectivity. [DOI] 10.1016/j.colsurfb.2022.113090 PMC 바로가기
Identification and characterization of the anti-SARS-CoV-2 activity of cationic amphiphilic steroidal compounds양이온성 양친매성 스테로이드 화합물의 항 SARS-CoV-2 활성의 확인 및 특성화Article Published on 2022-12-012022-09-11 Journal: Virulence [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제, [키워드] aggravation ameliorated anti-SARS-CoV-2 activities Anti-SARS-CoV-2 Activity Antiviral antiviral activity cationic caused cell lines characterization cholesterol complex Compound compounds COVID-19 pandemic COVID-19 patient cytopathic Cytopathic effect Drug discovery effective envelope envelope proteins epiandrosterone followed by hACE2 HEK293 host cell host cells identification in vitro in vivo indicated inhibited initial involved life Lipid mechanism membrane modulate modulation Mortality Pathogenesis progeny protective effect Protective effects Proteins Quality of life reduce reduce COVID-19 aggravation SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication selected Selection single mutation single mutations specific treatment spike steroidal compounds. subversion Transgenic mouse translate transmembrane Treatment treatment of COVID-19 patients Vero Vero CCL81 cell Vero CCL81 cells viral replication Viral RNA viral variant Viral variants [DOI] 10.1080/21505594.2022.2085793 PMC 바로가기 [Article Type] Article
Body weight, dietary intake, and health risk factors pre-COVID and during the COVID-19 pandemicResearch article Published on 2022-11-012022-10-05 Journal: Appetite [Category] 임상, 진단, 치료기술, [키워드] 2020 COVID-19 pandemic Administered appear body weight changes in cholesterol clinical clinical risk factor collected COVID COVID-19 COVID-19 pandemic decrease Diastolic blood pressure diet dietary intake fat Fat mass food Food Intake Fruit and vegetable intake Health Health risk factors hospital increase measure outcome measure risk factor Risk factors weight [DOI] 10.1016/j.appet.2022.106182 [Article Type] Research article
Enzymes in the time of COVID-19: An overview about the effects in the human body, enzyme market, and perspectives for new drugsArticle Published on 2022-11-012022-11-15 Journal: Medicinal research reviews [Category] COVID19(2023년), SARS, 치료제, [키워드] addition alanine aminotransferase angiotensin-converting enzyme-2 Aspartate aminotransferase Biomarkers cathepsin caused cholesterol contributed coronavirus COVID-19 drug drugs Effect effective effort enzyme enzyme market Enzymes Infection JAK/STAT pathway lactate dehydrogenase M pro mechanism of action metabolism pandemic Papain-like protease pathway Perspective protease reported Research rising SARS-CoV-2 SARS-COV-2 infection Serine syndrome target enzymes. transmembrane Treatment virus [DOI] 10.1002/med.21919 PMC 바로가기
Comparing the expression levels of tripartite motif containing 28 in mild and severe COVID-19 infectionArticle Published on 2022-10-032022-11-15 Journal: Virology Journal [Category] 치료제, [키워드] 25-hydroxyvitamin D age Analysis antiviral immune response association cholesterol control group coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 patients determine differential expression disease downregulation enrolled Epigenetic erythrocyte sedimentation rate ESR evaluated expression level HDL healthy control high-density in both group indicated Infection LDL low-density Mild mild infection motif mRNA level multivariate logistic regression Patient patients PCR cycle polymerase chain Proteins qPCR reduction in required Severe COVID-19 Infection severe group Severe infection severe infections severity severity of COVID-19 significantly lower the mean threshold TRIM28 Tripartite Motif Tripartite motif containing 28. was used [DOI] 10.1186/s12985-022-01885-0 PMC 바로가기
Amikacin-loaded niosome nanoparticles improve amikacin activity against antibiotic-resistant Klebsiella pneumoniae strainsArticle Published on 2022-10-032022-11-16 Journal: World journal of microbiology & biotechnology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Amikacin analyzed antibiotic Antibiotic-resistance Antibiotics Bacteria Bacterial infection Bacterial infections calculated Cell cholesterol Concentration Coverage cytotoxicity drug resistance drug-resistant evaluated Gene Expression highest hospitalized patients IMPROVE inhibited Klebsiella Klebsiella pneumoniae less MBC MDR mechanism mRNA expression multi-drug resistant Niosome Niosome. occur positive ranged reduced SARS-CoV-2 significantly Spread stability strain Strains Toxicity Treatment were measured [DOI] 10.1007/s11274-022-03405-2 PMC 바로가기
Antiviral efficacy of selective estrogen receptor modulators against SARS-CoV-2 infection in vitro and in vivo reveals bazedoxifene acetate as an entry inhibitor시험관 내 및 생체 내에서 SARS-CoV-2 감염에 대한 선택적 에스트로겐 수용체 조절제의 항바이러스 효능은 진입 억제제로서 바제독시펜 아세테이트를 나타냅니다Article Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] Acetate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-SARS-CoV-2 antiviral efficacy Bazedoxifene bazedoxifene acetate candidate cholesterol cholesterol distribution citrate clinical Clomifene Clomifene citrate contagious coronavirus Coronaviruses Critical delta variant distribution drugs Effect Efficacy endosome acidification Estrogen estrogen receptor evaluated exhibited expression hamster hamsters human cell lines humans identify in vitro in vivo infect Infection information inhibited inhibitor interleukin-6 offer omicron Omicron variant pathogenic variant penetration Postinfection pseudovirus pseudoviruses pulmonary viral reduced reveal SARS-CoV SARS-CoV-2 SARS-COV-2 infection selective selective estrogen receptor modulator severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Severe acute respiratory syndrome coronavirus 2. Tamoxifen toremifene toremifene citrate variant Vero E6 Vero E6 cell VERO E6 cells weight loss [DOI] 10.1002/jmv.27951 PMC 바로가기 [Article Type] Article
The evaluation of serum lipid profile in chronic Hepatitis B patients at a Tertiary Care Centre in Western India: A cross-sectional studyObservational Study Published on 2022-10-012023-06-12 Journal: Annals of African medicine [Category] B형 간염, [키워드] cholesterol chronic liver disease hepatitis B Hypolipidemia lipid metabolism. [DOI] 10.4103/aam.aam_35_21 PMC 바로가기 [Article Type] Observational Study
Tissue-specific pathway activities: A retrospective analysis in COVID-19 patientsArticle Published on 2022-09-152022-11-16 Journal: Frontiers in Immunology [Category] SARS, 치료기술, [키워드] ACE2 receptor activity Affect affected Alter anticoagulation arachidonic acid calculated changed changes in cholesterol Coagulation complement COVID-19 COVID-19 patient COVID-19 patients example expressed highlight Inflammation less linolenic acid lung Map mapped mechanism metabolism molecular multiple tissues non-COVID-19 patient organ other tissue pathway pathway activity Pathways progression Protein proteomics data RAS regulatory pathway reported Retrospective analysis SARS-CoV-2 SARS-COV-2 infection spleen the disease thrombosis Thyroid tissue tissue-specific proteomics data. tissues virus WikiPathways Wilcoxon test [DOI] 10.3389/fimmu.2022.963357 PMC 바로가기